Linked Life Data

6258882

Source:http://linkedlifedata.com/resource/pubmed/id/6258882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-5-26
pubmed:abstractText
To explore the haemodynamic consequences of the reduction in converting enzyme activity by acute alveolar hypoxia we made sequential haemodynamic observations in seven saline-infused and 12 bradykinin-infused anaesthetized, catheterized dogs. They were ventilated initially with room air and then for 50 minutes with hypoxic gas mixtures. Within two minutes after starting hypoxic ventilation, converting enzyme activity decreased, arterial angiotensin II concentrations dropped, and, in the bradykinin-infused dogs, arterial bradykinin concentrations rose. Both groups of dogs experienced a rise in systemic and pulmonary arterial blood pressure in response to hypoxia, but by different mechanisms. In the saline-infused (control) dogs there was increased systemic (+40%) and pulmonary (+90%) vascular resistance while cardiac output was unchanged or slightly reduced. Bradykinin-infused dogs demonstrated reduced systemic vascular resistance (-40%), no increase in pulmonary vascular resistance and a 100% increase in cardiac output. Return to room air breathing restored converting enzyme activity, releasing high concentrations of angiotensin II. Oxygen tension thus regulates converting enzyme activity and hence the circulating levels of angiotensin II and bradykinin.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-311
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Modulation of converting enzyme activity by hypoxia and its physiological effects.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't