rdf:type |
|
lifeskim:mentions |
umls-concept:C0007765,
umls-concept:C0016904,
umls-concept:C0027747,
umls-concept:C0030685,
umls-concept:C0220839,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1627358,
umls-concept:C1963578,
umls-concept:C2349975
|
pubmed:issue |
2
|
pubmed:dateCreated |
1981-5-21
|
pubmed:abstractText |
Cerebellar synaptosomes were superfused in the presence of D-[3H]aspartate (to label the glutamate 'reuptake pool') and [14C]glutamine (to label the 'new synthesis pool'). The depolarization-induced release of D-[3H]aspartate and of newly synthesized [14C]glutamate were potentiated by low concentrations of GABA (2--20 microM) or muscimol. The effect was probably mediated by the interaction of GABA with presynaptic GABA receptors localized in 'glutamergic' nerve endings, since it was antagonized by the GABA antagonists picrotoxin and bicuculline.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0006-8993
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
205
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
431-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6258717-Animals,
pubmed-meshheading:6258717-Aspartic Acid,
pubmed-meshheading:6258717-Cerebellum,
pubmed-meshheading:6258717-Glutamates,
pubmed-meshheading:6258717-Male,
pubmed-meshheading:6258717-Neural Inhibition,
pubmed-meshheading:6258717-Potassium,
pubmed-meshheading:6258717-Rats,
pubmed-meshheading:6258717-Receptors, Cell Surface,
pubmed-meshheading:6258717-Receptors, GABA-A,
pubmed-meshheading:6258717-Synaptic Transmission,
pubmed-meshheading:6258717-gamma-Aminobutyric Acid
|
pubmed:year |
1981
|
pubmed:articleTitle |
Enhancement by GABA of glutamate depolarization-induced release from cerebellar nerve endings.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|