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rdf:type |
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lifeskim:mentions |
umls-concept:C0002335,
umls-concept:C0003313,
umls-concept:C0027697,
umls-concept:C0034693,
umls-concept:C0036830,
umls-concept:C0051348,
umls-concept:C0567416,
umls-concept:C1167395,
umls-concept:C1517004,
umls-concept:C1527144,
umls-concept:C2603343
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pubmed:issue |
4
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pubmed:dateCreated |
1984-12-26
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pubmed:abstractText |
The effect of prostaglandin E1 alpha-cyclodextrin host molecule (PGE1 . CD) was estimated by using a model of immune complex glomerulonephritis induced in rats by i.v. injection of 1 mg of rabbit serum albumin every other day. PGE1 . CD was given subcutaneously for 10 days after nephritis was definitely induced and resulted in a rapid restoration of various biochemical parameters, especially in plasma. The continuous s.c. administration of PGE1 . CD (300 micrograms/rat/day) with a mini osmotic pump provoked a therapeutic effect similar to that obtained with twice daily s.c. administration of PGE1 . CD (300 micrograms/rat X 2/day). Both PGE1 . CD groups revealed less glomerular damage and fewer locations of immune complexes in glomeruli as demonstrated by light and immunofluorescence microscopy. The beneficial effect of PGE1 . CD may be associated with reduced immune complex deposits in glomeruli. The present studies suggest that PGE1 . CD may enhance the clearance of immune complex deposits from the glomeruli rather than inhibiting the formation of immune complex in the circulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-5198
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
407-14
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6239050-Acetylglucosaminidase,
pubmed-meshheading:6239050-Alkaline Phosphatase,
pubmed-meshheading:6239050-Alprostadil,
pubmed-meshheading:6239050-Animals,
pubmed-meshheading:6239050-Body Weight,
pubmed-meshheading:6239050-Cyclodextrins,
pubmed-meshheading:6239050-Dextrins,
pubmed-meshheading:6239050-Fluorescent Antibody Technique,
pubmed-meshheading:6239050-Guanosine Triphosphate,
pubmed-meshheading:6239050-Hyperlipidemias,
pubmed-meshheading:6239050-Immune Complex Diseases,
pubmed-meshheading:6239050-Kidney Glomerulus,
pubmed-meshheading:6239050-Male,
pubmed-meshheading:6239050-Nephritis,
pubmed-meshheading:6239050-Prostaglandins E,
pubmed-meshheading:6239050-Proteinuria,
pubmed-meshheading:6239050-Rats,
pubmed-meshheading:6239050-Rats, Inbred Strains,
pubmed-meshheading:6239050-Starch,
pubmed-meshheading:6239050-Time Factors,
pubmed-meshheading:6239050-Uremia,
pubmed-meshheading:6239050-alpha-Cyclodextrins
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pubmed:year |
1984
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pubmed:articleTitle |
Studies on experimental immune complex nephritis (3). Therapeutic effect of prostaglandin E1 alpha-cyclodextrin host molecule (PGE1 . CD) on serum sickness nephritis in rats.
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pubmed:publicationType |
Journal Article
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