| pubmed-article:6235836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6235836 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:6235836 | lifeskim:mentions | umls-concept:C0002874 | lld:lifeskim |
| pubmed-article:6235836 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:6235836 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:6235836 | lifeskim:mentions | umls-concept:C1304884 | lld:lifeskim |
| pubmed-article:6235836 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6235836 | pubmed:dateCreated | 1984-10-24 | lld:pubmed |
| pubmed-article:6235836 | pubmed:abstractText | Lymphocyte subsets have been measured in the blood of 28 patients with aplastic anaemia. The mean helper/inducer:suppressor/cytotoxic T lymphocyte ratio (1.24 +/- 0.74) was significantly decreased in the total population in comparison to mean ratios in a normal population (1.78 +/- 0.57) and in patients with other haematological diseases (1.82 +/- 0.92). A reversed ratio (less than or equal to 1) was present in a large proportion (53%) of aplastic patients, due both to an absolute deficiency of helper/inducer lymphocytes and an increase in suppressor/cytotoxic lymphocytes. Increased HLA-DR expression, evidence of lymphocyte activation, was present in seven of 12 patients evaluated and was confined to the suppressor/cytotoxic lymphocyte population. In the bone marrow, the percentage of lymphocytes was increased two-fold compared to normal bone marrow but the ratio of T cell subsets was not abnormal. Two of four patients evaluated after haematopoietic recovery following ATG treatment showed a return to normal of the T4/T8 ratio; in two others a low T4/T8 ratio persisted despite recovery. These results indicate that lymphocyte subset imbalance and lymphocyte activation are present in many patients with aplastic anaemia, either as a contributing factor or as a result of bone marrow failure. | lld:pubmed |
| pubmed-article:6235836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6235836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6235836 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6235836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6235836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6235836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6235836 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6235836 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:YoungNN | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:HsuS MSM | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:GoodmanSS | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:GriffithPP | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:NienhuisA WAW | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:SharrowS OSO | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:HumphriesR... | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:ZoumbosN CNC | lld:pubmed |
| pubmed-article:6235836 | pubmed:author | pubmed-author:FerrisW OWO | lld:pubmed |
| pubmed-article:6235836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6235836 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:6235836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6235836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6235836 | pubmed:pagination | 95-105 | lld:pubmed |
| pubmed-article:6235836 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:6235836 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6235836 | pubmed:articleTitle | Analysis of lymphocyte subsets in patients with aplastic anaemia. | lld:pubmed |
| pubmed-article:6235836 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6235836 | lld:pubmed |
