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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-10-24
|
| pubmed:abstractText |
Lymphocyte subsets have been measured in the blood of 28 patients with aplastic anaemia. The mean helper/inducer:suppressor/cytotoxic T lymphocyte ratio (1.24 +/- 0.74) was significantly decreased in the total population in comparison to mean ratios in a normal population (1.78 +/- 0.57) and in patients with other haematological diseases (1.82 +/- 0.92). A reversed ratio (less than or equal to 1) was present in a large proportion (53%) of aplastic patients, due both to an absolute deficiency of helper/inducer lymphocytes and an increase in suppressor/cytotoxic lymphocytes. Increased HLA-DR expression, evidence of lymphocyte activation, was present in seven of 12 patients evaluated and was confined to the suppressor/cytotoxic lymphocyte population. In the bone marrow, the percentage of lymphocytes was increased two-fold compared to normal bone marrow but the ratio of T cell subsets was not abnormal. Two of four patients evaluated after haematopoietic recovery following ATG treatment showed a return to normal of the T4/T8 ratio; in two others a low T4/T8 ratio persisted despite recovery. These results indicate that lymphocyte subset imbalance and lymphocyte activation are present in many patients with aplastic anaemia, either as a contributing factor or as a result of bone marrow failure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
95-105
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6235836-Adolescent,
pubmed-meshheading:6235836-Adult,
pubmed-meshheading:6235836-Aged,
pubmed-meshheading:6235836-Anemia, Aplastic,
pubmed-meshheading:6235836-Antilymphocyte Serum,
pubmed-meshheading:6235836-Bone Marrow,
pubmed-meshheading:6235836-Female,
pubmed-meshheading:6235836-HLA-DR Antigens,
pubmed-meshheading:6235836-Histocompatibility Antigens Class II,
pubmed-meshheading:6235836-Humans,
pubmed-meshheading:6235836-Leukocyte Count,
pubmed-meshheading:6235836-Lymphocyte Activation,
pubmed-meshheading:6235836-Lymphocytes,
pubmed-meshheading:6235836-Male,
pubmed-meshheading:6235836-Middle Aged,
pubmed-meshheading:6235836-T-Lymphocytes,
pubmed-meshheading:6235836-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:6235836-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6235836-T-Lymphocytes, Regulatory
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Analysis of lymphocyte subsets in patients with aplastic anaemia.
|
| pubmed:publicationType |
Journal Article
|