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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1983-11-23
|
| pubmed:abstractText |
To characterize the inflammatory infiltrate of chronic active hepatitis we have examined 26 liver biopsy specimens [16 hepatitis B surface antigen-negative and 10 hepatitis B surface antigen-positive] with monoclonal antibodies and antiimmunoglobulins that react against the following mononuclear cell populations: T cells, T4 cells, T8 cells, monocytes-macrophages, Ia-positive cells, surface Ig-bearing cells, natural killer/killer cells. A biotin-avidin-fluorescein technique was used and the number of positive cells was counted in a portal tract that was more severely involved. The T cells predominate in all the specimens. The T4:T8 cell ratio and the number of T and T4 cells in the hepatitis B surface antigen-negative patients are higher than in the hepatitis B surface antigen-positive patients. While natural killer/killer cells, surface Ig-bearing cells, and macrophages are always rare, Ia-positive cells are numerous and the double-staining technique demonstrates a fair number of cells displaying both T-cell and Ia markers. These findings, while not supporting a major role of killer cells in chronic active hepatitis, suggest a different alteration of T-cell subsets in hepatitis B surface antigen-positive and -negative chronic active hepatitis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0016-5085
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1138-45
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:6225691-Adult,
pubmed-meshheading:6225691-Antibodies, Monoclonal,
pubmed-meshheading:6225691-Biopsy,
pubmed-meshheading:6225691-Cell Count,
pubmed-meshheading:6225691-Female,
pubmed-meshheading:6225691-Fluorescent Antibody Technique,
pubmed-meshheading:6225691-Hepatitis, Chronic,
pubmed-meshheading:6225691-Hepatitis B,
pubmed-meshheading:6225691-Hepatitis B Surface Antigens,
pubmed-meshheading:6225691-Histocompatibility Antigens Class II,
pubmed-meshheading:6225691-Humans,
pubmed-meshheading:6225691-Killer Cells, Natural,
pubmed-meshheading:6225691-Liver,
pubmed-meshheading:6225691-Male,
pubmed-meshheading:6225691-Monocytes,
pubmed-meshheading:6225691-T-Lymphocytes,
pubmed-meshheading:6225691-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6225691-T-Lymphocytes, Regulatory
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
In situ characterization by monoclonal antibodies of the mononuclear cell infiltrate in chronic active hepatitis.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|