Linked Life Data

6225513

Source:http://linkedlifedata.com/resource/pubmed/id/6225513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1983-11-23
pubmed:abstractText
Previous studies have shown that prolonged estrogen treatment of mice markedly reduces their natural killer (NK) cell activity. Our experiments demonstrate that splenocytes from (C57BL/6 X C3H/He) F1 mice treated with 17 beta-estradiol are suppressive for the NK activity of splenocytes from untreated mice when the two cell populations are mixed during cytotoxicity assays. The suppressor activity is resistant to treatment with anti-Thy-1.2 or anti-la reagent plus complement, can be generated in neonatally thymectomized mice, and is present in plastic-adherent as well as nonadherent cell populations. Treatment with a NK-reactive antiserum, either anti-asialo-GM-1 or anti-NK-1.2, has no effect on the suppressor activity. Administration of the interferon inducer polyinosinic-polycytidylic acid to mice treated with estrogen results in moderate restoration of NK activity but has no effect on the suppressor activity. These data suggest that generation of a Thy-1-negative/la-negative suppressor cell population is, at least in part, responsible for the reduced levels of NK activity in estrogen-treated mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5240-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Role of suppressor cells in the decline of natural killer cell activity in estrogen-treated mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't