Linked Life Data

6216839

Source:http://linkedlifedata.com/resource/pubmed/id/6216839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-1-19
pubmed:abstractText
We studied the effects of continuous positive airway pressure (CPAP) in 8 asthmatic subjects in whom bronchospasm was induced by aerosolized histamine. The CPAP (12.0 +/- 0.9 cm H2O) increased functional residual capacity by only 0.27 +/- 0.12 L, raised the minimal pleural pressure (Ppl) during inspiration from -32.3 +/- 2.6 cm H2O to -22.8 +/- 2.3 cm H2O (p less than 0.01), and decreased the swings in transdiaphragmatic pressure (Pdi) from 35.1 +/- 2.4 cm H2O to 29.6 +/- 3.7 cm H2O (p less than 0.05). Although ventilation (VE) increased, the inspiratory work per liter of VE fell significantly. More importantly, the pressure-time product for the inspiratory muscles (integral of Ppl.dl) measured over 60 s, fell from 830 +/- 111 to 573 +/- 41 cm H2O.s (p less than 0.05), whereas that for the diaphragm (integral of Pdi.dt) fell from 690 +/- 91 to 497 +/- 74 cm H2O.s (p less than 0.05). We conclude that in induced asthma, CPAP reduces the load on the inspiratory muscles, improving their efficiency and decreasing the energy cost of their action. Our results justify further investigation into the role of CPAP in the treatment of respiratory failure caused by severe bronchial asthma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
812-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of continuous positive airway pressure on respiratory mechanics and pattern of breathing in induced asthma.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't