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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Suppl
|
| pubmed:dateCreated |
1982-12-21
|
| pubmed:abstractText |
Previous studies have suggested functional heterogeneity within the OKT4+ and the OKT8+ populations. For example, after activation the OKT4+ population contains not only helper cells but also cells capable of suppressing B cell differentiation. Previous studies also indicate that the reciprocal T cell population, OKT8+, does not provide helper activity but contains cytotoxic effector cells and radiosensitive cells important in the suppression of B cell differentiation. Using a new differentiation antigen, OKT17, which recognizes a surface antigen present on the majority of resting normal peripheral T lymphocytes but is present only on a subset of OKT4+ cells after activation, evidence was obtained that two functionally mature subsets can be distinguished within the OKT4+ population itself: OKT4+17+ radiosensitive suppressor cells and OKT4+17- radiosensitive helper cells. Recently, another monoclonal antibody, OKT20, has been described which is present on a small percentage of resting lymphocytes but is expressed in varying proportions on activated T cells. Functional analysis of normal resting human T lymphocytes demonstrated that the OKT20-depleted T cell subset was able to generate cytotoxic cells and to suppress antibody production to the same extent as did OKT8+ cells. On the other hand, when unselected T lymphocytes were cultured for six days in a mixed lymphocyte reaction and then depleted of OKT20 reactive cells, the cytotoxic effector T cells were eliminated. In contrast, OKT20-depleted T cells after identical activation were still able to suppress antibody production. These data provide evidence that following activation of OKT8+ cells, the OKT20 differentiation antigen becomes selectively expressed on cytotoxic effectors but not on suppressor cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0271-9142
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
8S-14S
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6215426-Antibodies, Monoclonal,
pubmed-meshheading:6215426-Antibody-Producing Cells,
pubmed-meshheading:6215426-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:6215426-Antigens, Heterophile,
pubmed-meshheading:6215426-Antigens, Surface,
pubmed-meshheading:6215426-B-Lymphocytes,
pubmed-meshheading:6215426-Hemolytic Plaque Technique,
pubmed-meshheading:6215426-Humans,
pubmed-meshheading:6215426-T-Lymphocytes,
pubmed-meshheading:6215426-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:6215426-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6215426-T-Lymphocytes, Regulatory
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Further dissection of the functional heterogeneity within the OKT4+ and OKT8+ human T cell subsets.
|
| pubmed:publicationType |
Journal Article
|