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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1982-12-2
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pubmed:abstractText |
The effect of alloxan and streptozotocin on the fluxes of Ca2+ in isolated mouse liver mitochondria was studied with dual wave-length spectrophotometry, using antipyrylazo III as metallochromic indicator. Streptozotocin had no effect on Ca2+ uptake, whereas alloxan inhibited the initial rate and extent of Ca2+ influx in a way dependent on the duration of preincubation, and occurrence of Pi in the reaction mixture. A rapid release of Ca2+ followed upon addition of either FCCP or alloxan after the reaction had been started. When added to preloaded mitochondria, alloxan induced a concentration dependent release of Ca2+. The data suggest that alloxan induces an initial release of mitochondrial Ca2+, which is followed by inhibition of Ca2+ influx. The initial release may be due to uncoupler activity induced by alloxan, and the inhibition of Ca2+ influx may be a consequence of inhibited Pi transport.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alloxan,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonyl Cyanide...,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0143-4160
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6214312-Alloxan,
pubmed-meshheading:6214312-Animals,
pubmed-meshheading:6214312-Calcium,
pubmed-meshheading:6214312-Calcium Chloride,
pubmed-meshheading:6214312-Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone,
pubmed-meshheading:6214312-Male,
pubmed-meshheading:6214312-Mice,
pubmed-meshheading:6214312-Mice, Inbred C57BL,
pubmed-meshheading:6214312-Mitochondria, Liver,
pubmed-meshheading:6214312-Streptozocin,
pubmed-meshheading:6214312-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Effects of alloxan and streptozotocin on calcium transport in isolated mouse liver mitochondria.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|