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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
1984-12-27
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pubmed:abstractText |
During the period from September, 1976 to June, 1979, 70 patients with locoregional or extensive epidermoid carcinoma of the esophagus were treated with the two-drug combination of cisplatin and bleomycin (DB). For the 43 patients with locoregional disease (LRD), DB was used prior to surgery and/or radiation therapy; it was the primary treatment for 27 patients with extensive disease (ED). The major objective response rates [complete remission (CR) and partial remission (PR)] to DB for the LRD and ED groups were 14% and 17%, respectively, for an overall response rate of 15%. For the LRD group, the minimum follow-up was 42 months; four patients (10%) remain alive and free of disease. The median survival of 34 patients treated with DB preoperatively was 10 months, which did not differ significantly from that of a historic control group receiving preoperative radiation therapy. The median duration of response for ED patients was 6 months, and the median survival for the entire ED group was 4 months. DB alone had only modest activity in epidermoid carcinoma of the esophagus.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2351-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6208990-Adult,
pubmed-meshheading:6208990-Aged,
pubmed-meshheading:6208990-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:6208990-Bleomycin,
pubmed-meshheading:6208990-Carcinoma, Squamous Cell,
pubmed-meshheading:6208990-Cisplatin,
pubmed-meshheading:6208990-Clinical Trials as Topic,
pubmed-meshheading:6208990-Esophageal Neoplasms,
pubmed-meshheading:6208990-Female,
pubmed-meshheading:6208990-Follow-Up Studies,
pubmed-meshheading:6208990-Humans,
pubmed-meshheading:6208990-Male,
pubmed-meshheading:6208990-Middle Aged,
pubmed-meshheading:6208990-Neoplasm Staging
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pubmed:year |
1984
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pubmed:articleTitle |
Cisplatin and bleomycin in the treatment of esophageal carcinoma. A final report.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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