Linked Life Data

6205883

Source:http://linkedlifedata.com/resource/pubmed/id/6205883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-10-11
pubmed:abstractText
Human Thy-1 glycoprotein was purified from brain cortex membranes. Antibodies were produced in rabbits by immunization with purified Thy-1 and with brain homogenate. Both preparations of antibodies reacted with monomers of 125I-labeled Thy-1. In addition, the antibodies against the purified antigen also recognized a determinant which was absent, or present in very low amounts, in homogenates of human brain. Analysis by gel filtration in Nonidet-P40 or deoxycholate revealed the presence of complexes of purified Thy-1 that were specifically precipitated by antibodies against this determinant. It was also shown that anti-monomer antibodies were unable to react with the complex form of Thy-1. These complexes seemed to be composed of a varying number of Thy-1 molecules. By treatment with sodium dodecyl sulfate, the multimers were completely dissociated into monomers. The tendency to complex formation seems to be unique for human Thy-1, since Thy-1 analogues of other species do not show this property when isolated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
734-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Identification of a neodeterminant in complexes of human brain Thy-1.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't