Linked Life Data

6203363

Source:http://linkedlifedata.com/resource/pubmed/id/6203363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1984-7-25
pubmed:abstractText
Substance P is present in sensory nerves in the lung and we report here its actions on the lung strip. Substance P was shown to produce rapid, small contractions of trhe lung strip at doses from 10(-9) to 10(-5) M, and there was no apparent dose-response relationship. In the presence of a mixture of three inhibitors of substance P breakdown: bacitracin, 1,4-dithio-L- threitol and ethylenediaminetetra-acetic acid all at 10(-4) M, the responses to substance P were greatly increased and dose-response curves could be established. The concentrations producing half maximal effect in the presence of these inhibitors were 6 X 10(-6) M +/- 4 X 10(-6) M. The inhibitors of substance P breakdown were found to have no effect on the histamine dose-response curve: any small shifts obtained were not significant. Chlorpheniramine 10(-6) M and 10(-5) M shifted the histamine dose-response curve to the right producing dose ratios of 100 and 900 respectively. At these doses chlorpheniramine had no effect on the dose-response curve to substance P. A dose of substance P not itself producing a response (5 X 10(-8) M) caused an increase in the size of the responses to histamine. The histamine dose-response curve was shifted to the left in the presence of substance P producing an average dose ratio of 1.4 +/- 0.2. In the presence of the peptidase inhibitors, dose-response curves have also been produced for physalaemin (10(-7) - 10(-5) M) and eledoisin (10(-7) - 10(-5) M).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The effect of substance P and related peptides on the guinea-pig lung strip.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't