Linked Life Data

6200131

Source:http://linkedlifedata.com/resource/pubmed/id/6200131

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-5-11
pubmed:abstractText
Transplantation of haematopoietic tissue from the fetus to the adult is of considerable clinical and theoretical interest. In particular it could help to understand whether the haemoglobin switch is under the influence of environmental factors or inherently programmed in the haemopoietic cell population. In the present study we have monitored haemoglobin synthesis following fetal liver transplantation (FLT) in a patient with acute leukaemia after intensive chemoradiotherapy. 28 days following FLT, the haemoglobin synthesis showed a predominantly fetal haemoglobin pattern, as determined by globin chain synthesis of bone marrow cells and by the peroxidase anti-peroxidase (PAP) method applied to bone marrow sections treated with anti-fetal haemoglobin antibodies. These findings demonstrate that, in man, fetal haemopoietic cells, transplanted into an adult environment, do not immediately switch to the production of adult haemoglobin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-14
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Fetal haemoglobin synthesis following fetal liver transplantation in man.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't