Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-2-14
pubmed:abstractText
We studied the effect of aprotinin, a reversible inhibitor of kallikrein and other serine proteases, upon urinary kallikrein and kinin excretion, renal function and hemodynamics, blood pressure, and plasma renin activity (PRA). When aprotinin was administered to anesthetized rats at 10,000 KIU/kg as a bolus, and at 1000 KIU/kg/min infusion for 60 minutes, urinary kininogenase activity and immunoreactive kallikrein, kinins, sodium, potassium, and water excretion, and PRA decreased significantly. Aprotinin also caused a 36% decrease (p less than 0.001) in renal blood flow (RBF), and a 37% decrease (p less than 0.001) in glomerular filtration rate (GFR), although neither blood pressure nor cardiac output changed. The effect of aprotinin on PRA was further studied in conscious rats before and after stimulation of renin release by isoproterenol or furosemide. Aprotinin (5,000 KIU/kg bolus and 1000 KIU/kg/min infusion for 60 minutes) did not alter basal or isoproterenol-stimulated PRA, but it blunted the increase in PRA as stimulated by furosemide. Aprotinin at a higher dose (20,000 KIU/kg bolus and 5000 KIU/kg/min infusion for 60 minutes) significantly lowered blood pressure and increased hematocrit and PRA. These effects may be due to inhibition of serine protease(s) or to other as yet unrecognized properties of this peptide resulting from its highly cationic nature. In conclusion, aprotinin at a low dose decreased kallikrein, kinin, sodium, and water excretion. These decreases may be due to the inhibition of kallikrein and/or other serine proteases or may be secondary to the renal hemodynamic changes.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0194-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
893-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:6197374-Animals, pubmed-meshheading:6197374-Aprotinin, pubmed-meshheading:6197374-Blood Pressure, pubmed-meshheading:6197374-Cardiac Output, pubmed-meshheading:6197374-Diuresis, pubmed-meshheading:6197374-Furosemide, pubmed-meshheading:6197374-Glomerular Filtration Rate, pubmed-meshheading:6197374-Isoproterenol, pubmed-meshheading:6197374-Kallikreins, pubmed-meshheading:6197374-Kidney, pubmed-meshheading:6197374-Kinins, pubmed-meshheading:6197374-Male, pubmed-meshheading:6197374-Natriuresis, pubmed-meshheading:6197374-Protease Inhibitors, pubmed-meshheading:6197374-Rats, pubmed-meshheading:6197374-Rats, Inbred Strains, pubmed-meshheading:6197374-Renal Circulation, pubmed-meshheading:6197374-Renin, pubmed-meshheading:6197374-Serine Endopeptidases, pubmed-meshheading:6197374-Stimulation, Chemical
pubmed:articleTitle
The effect of aprotinin (a serine protease inhibitor) on renal function and renin release.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't