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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-12-17
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pubmed:abstractText |
Influenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production. The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2. Conversely, the T cells that produced IL-2 were unable to provide either specific or non-specific helper function. These findings indicated the IL-2 is not an essential component for helper activity. However, phenotypic analysis revealed that both the functional subsets of T-cell clones expressed the helper phenotype in that they were T4+, T3+ and T11+. Nevertheless analysis with other antibodies revealed differences in that the IL-2 releasing clone showed greater staining with the anti-T-cell subset antibodies 9.3 and Leu 8, confirming that there is phenotype as well as functional heterogeneity within the helper inducer T-cell population.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6165078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6172480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6176330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6177819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6180903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6214586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6216957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6752327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6795507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6806171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6807607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6809822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6965306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-6975347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6195096-7334214
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-405
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6195096-Antibodies, Viral,
pubmed-meshheading:6195096-Antigens, Surface,
pubmed-meshheading:6195096-Clone Cells,
pubmed-meshheading:6195096-Epitopes,
pubmed-meshheading:6195096-Humans,
pubmed-meshheading:6195096-Interleukin-2,
pubmed-meshheading:6195096-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6195096-Orthomyxoviridae,
pubmed-meshheading:6195096-T-Lymphocytes,
pubmed-meshheading:6195096-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1983
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pubmed:articleTitle |
The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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