Linked Life Data

6194107

Source:http://linkedlifedata.com/resource/pubmed/id/6194107

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-11-23
pubmed:abstractText
The differences between the immune response (Ir) phenotypes of H-2 gene-controlled high- and low-responder mice have been attributed to events occurring at the interaction between antigen-presenting cells (APC) and lymphocytes. To investigate this interaction we undertook a study of molecular events in the processing of avidin, a molecule whose uniquely strong affinity for binding to biotin renders it traceable at very low concentrations, and a molecule to which the T-lymphocyte immune response is controlled by Ir genes. In this paper we describe the generation of processed avidin by APC and characterize it biochemically and immunologically. We found that APC of H-2 genetically high- and low-responder mice were indistinguishable in their capacity to generate immunogenic processed avidin (PA). Immunogenic PA differed from native avidin in size and carbohydrate moieties, but preserved its capacity to bind biotin, and was 1000-fold more efficient than NA as an immunogen for primed T lymphocytes. Primed T lymphocytes appeared to recognize PA that was conformationally intact. Highly immunogenic PA was not H-2 restricted. Thus, differences in the Ir phenotype of the response to avidin could not be attributed to determinant selection by APC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0093-7711
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-90
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Molecular events in the processing of avidin by antigen-presenting cells (APC). II. Identical processing by APC of H-2 high- and low-responder mouse strains.
pubmed:publicationType
Journal Article