Linked Life Data

6191694

Source:http://linkedlifedata.com/resource/pubmed/id/6191694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1983-8-26
pubmed:abstractText
Potentiation of the cytotoxic effects of 5-fluorouracil (5-FU) by interferon on human tumor cells was examined. The human neoplastic cell lines used were HeLa (uterine cervical cancer), MCF-7 (mammary cancer), WI-38 CT-1 (embryonic lung fibroblasts transformed in culture by Co-60 gamma-ray irradiation), KMM-1 (myeloma), and Raji (Burkitt's lymphoma). As a normal human cell strain, WI-38 (embryonic lung fibroblasts) was used. The cytotoxic effects were determined by colony formation. Each cell line was different in sensitivity to interferon or 5-FU. Interferon potentiated synergistically the cytotoxic effects of 5-FU on HeLa, WI-38 CT-1, and KMM-1 cells. In the case of Raji cells, the cytotoxic effects of the combination of interferon and 5-FU were additive. Neither synergistic nor additive lethal effects of the combination of the two agents were observed in MCF-7 and WI-38 cells. The present results indicate a possibility that a combined treatment with interferon and 5-FU may be effective in certain types of human cancers.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2207-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Combined effects of 5-fluorouracil and interferon on proliferation of human neoplastic cells in culture].
pubmed:publicationType
Journal Article, English Abstract