| pubmed-article:6184720 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
| pubmed-article:6184720 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6184720 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:6184720 | pubmed:dateCreated | 1983-2-25 | lld:pubmed |
| pubmed-article:6184720 | pubmed:abstractText | Persisting (P) cells (murine cells that resemble mast cells and grow continuously in vitro for prolonged periods in the presence of a specific growth factor) did not express detectable levels of Ia antigens (murine class II major histocompatibility antigens) when their growth was supported by partially purified P cell-stimulating factor. However, when these Ia-negative P cells were transferred to medium conditioned by concanavalin A-stimulated spleen cells, Ia antigens appeared within 24 hr. The increase in Ia antigens was due to induction of synthesis of Ia antigens by P cells and not to absorption of Ia antigens from the conditioned medium or selective growth of Ia-positive cells from a low number of Ia-positive cells in the original population. The Ia-inducing activity was also found in supernatants from antigen-stimulated cloned T-cell lines, but not from certain T-cell hybridomas or the T lymphoma EL-4. The presence of Ia-inducing activity correlated with the presence of interferon-gamma (IFN-gamma). The gel filtration profiles of IFN-gamma activity and Ia-inducing activity were coincident and corresponded to an apparent molecular weight of 40,000-45,000. Both the IFN-gamma and Ia-inducing activity were destroyed by treatment at pH 2. These results indicate that IFN-gamma or a closely related molecule induces Ia antigens on P cells and suggest that regulation of Ia antigen expression may be an important aspect of the effects of IFN-gamma on the immune and hemopoietic systems. | lld:pubmed |
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| pubmed-article:6184720 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6184720 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6184720 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6184720 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6184720 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6184720 | pubmed:author | pubmed-author:SchraderJ WJW | lld:pubmed |
| pubmed-article:6184720 | pubmed:author | pubmed-author:Clark-LewisII | lld:pubmed |
| pubmed-article:6184720 | pubmed:author | pubmed-author:WongG HGH | lld:pubmed |
| pubmed-article:6184720 | pubmed:author | pubmed-author:McKimm-Bresch... | lld:pubmed |
| pubmed-article:6184720 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6184720 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:6184720 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6184720 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6184720 | pubmed:pagination | 6989-93 | lld:pubmed |
| pubmed-article:6184720 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6184720 | pubmed:meshHeading | pubmed-meshheading:6184720-... | lld:pubmed |
| pubmed-article:6184720 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6184720 | pubmed:articleTitle | Interferon-gamma-like molecule induces Ia antigens on cultured mast cell progenitors. | lld:pubmed |
| pubmed-article:6184720 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6184720 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6184720 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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