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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1983-2-25
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pubmed:abstractText |
Persisting (P) cells (murine cells that resemble mast cells and grow continuously in vitro for prolonged periods in the presence of a specific growth factor) did not express detectable levels of Ia antigens (murine class II major histocompatibility antigens) when their growth was supported by partially purified P cell-stimulating factor. However, when these Ia-negative P cells were transferred to medium conditioned by concanavalin A-stimulated spleen cells, Ia antigens appeared within 24 hr. The increase in Ia antigens was due to induction of synthesis of Ia antigens by P cells and not to absorption of Ia antigens from the conditioned medium or selective growth of Ia-positive cells from a low number of Ia-positive cells in the original population. The Ia-inducing activity was also found in supernatants from antigen-stimulated cloned T-cell lines, but not from certain T-cell hybridomas or the T lymphoma EL-4. The presence of Ia-inducing activity correlated with the presence of interferon-gamma (IFN-gamma). The gel filtration profiles of IFN-gamma activity and Ia-inducing activity were coincident and corresponded to an apparent molecular weight of 40,000-45,000. Both the IFN-gamma and Ia-inducing activity were destroyed by treatment at pH 2. These results indicate that IFN-gamma or a closely related molecule induces Ia antigens on P cells and suggest that regulation of Ia antigen expression may be an important aspect of the effects of IFN-gamma on the immune and hemopoietic systems.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-278865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-302314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-4356326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-59972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6157486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6160587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6162887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6168393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6172487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6173083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6174674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6177763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6179079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6180027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6448907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6450260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6795264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6965319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6969751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6969776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6970213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6972532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6976369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-6976370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-7009407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-7015151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-7022228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-7022229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-71738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-7188699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6184720-83651
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6989-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6184720-Animals,
pubmed-meshheading:6184720-Biological Assay,
pubmed-meshheading:6184720-Bone Marrow,
pubmed-meshheading:6184720-Cells, Cultured,
pubmed-meshheading:6184720-Clone Cells,
pubmed-meshheading:6184720-Epitopes,
pubmed-meshheading:6184720-Genes, MHC Class II,
pubmed-meshheading:6184720-Interferon-gamma,
pubmed-meshheading:6184720-Mast Cells,
pubmed-meshheading:6184720-Mice,
pubmed-meshheading:6184720-Mice, Inbred CBA,
pubmed-meshheading:6184720-Semliki forest virus,
pubmed-meshheading:6184720-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
Interferon-gamma-like molecule induces Ia antigens on cultured mast cell progenitors.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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