Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1982-12-21
pubmed:abstractText
The effect of the alpha2-antagonist, yohimbine, on cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol (MHPG), dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindolactic acid (5-HIAA) concentrations was studied in vivo. Cerebrospinal fluid was removed at a constant flow rate of 1 microliters/min from the third ventricle of rats and directly analysed by liquid chromatography coupled with electrochemical detection. An intracerebroventricular injection of yohimbine (100 nmol) dramatically increased MHPG levels. These results suggest a functional stimulation of alpha-2 adrenoceptors modulating noradrenergic neurotransmission in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Central administration of yohimbine increases free 3-methoxy-4-hydroxyphenylglycol in the cerebrospinal fluid of the rat.
pubmed:publicationType
Journal Article