Linked Life Data

6161861

Source:http://linkedlifedata.com/resource/pubmed/id/6161861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-4-24
pubmed:abstractText
Polyclonal and monoclonal antibodies have been produced to Mallory body protein (MBP) extracted from isolated Mallory bodies (MBs). The polyclonal antibodies reveal a unique determinant in MBs. The first monoclonal antibody (anti-JMB1) detects a second unique determinant (JMB1) in MBs which is not detectable in normal hepatocytes. The second monoclonal antibody (anti-JMB2) shows that MBs contain another determinant which is associated with the cell and nuclear membranes and a cytoplasmic filament system of normal hepatocytes and bile duct epithelium; this antigen is not detectable in the cell membranes or cytoplasmic filament systems of hepatocytes which contain MBs. The third monoclonal antibody (anti-JMB3) reacts only with an antigen (JMB3) in mesenchymal cells of alcoholic cirrhotic liver and its significance, at this time, is unclear. It is suggested that the metabolism of JMB1, JMB2, and JMB3 antigens is deranged in hepatocytes damaged by alcohol. It is concluded that the antigenic structure of MBs is more complex than hitherto realised and that all of these antigens are distinct from prekeratin (a component of epidermal cell intermediate filaments).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-219290, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-283168, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-386356, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-4111510, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-4117027, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-51133, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-55371, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-7000633, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-72016, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-761016, http://linkedlifedata.com/resource/pubmed/commentcorrection/6161861-95015
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Mallory bodies in alcoholic liver disease: identification of cytoplasmic filament/cell membrane and unique antigenic determinants by monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't