Linked Life Data

6158415

Source:http://linkedlifedata.com/resource/pubmed/id/6158415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1980-12-18
pubmed:abstractText
Previous work had shown that some of the effects of catechol could be via the fusimotor system. In order to determine the extent of fusimotor involvement, recordings have been made from muscle spindle afferents in split dorsal root filaments of anaesthetised rats. Catechol failed to excite de-efferented muscle spindles therefore eliminating many possible non-fusimotor effects. Over 80% of spindle afferents with intact efferents showed increased discharge frequency 1 min after injection, this increase often following a biphasic pattern with a pronounced pre-myoclonic burst and decline followed by a more sustained period of activity during the myoclonic phase. Analysis of spontaneous twitches or twitches evoked by ipsilateral auditory stimulation showed in addition a phasic increase in discharge suggesting alpha-gamma co-activation. Both primary and secondary afferents from many muscle groups around ankle and toes had their discharge frequencies elevated. Elevation of discharge frequencies of secondaries implies increased gamma-s activity confirmed by a decrease in dynamic index. Both gamma-d and gamma-s involvement in catechol action on primaries is suggested by dynamic index measurements. Perhaps a more continuous form of testing such as sinusoidal stretches would reveal any rapid switching between activities in the two systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-81
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of catechol on the discharge of muscle spindle afferents from the hind limb of the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't