Linked Life Data

6157769

Source:http://linkedlifedata.com/resource/pubmed/id/6157769

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1980-11-25
pubmed:abstractText
HLA public antigens X and Y have been shown to be common determinants on the heavy chains of molecules belonging to the HLA-B7 and HLA-B5 cross-reactive groups (CREG), respectively. The ability of these antigens to act as targets for cytotoxic lymphocytes was investigated. After stimulating B7-CREG cells in an in vitro primary and secondary culture with mitomycin-treated B27-positive cells, the effector cells generated lysed cells bearing B7, Bw22, B27, or B40, all of which bear X. No lysis was seen with cells not bearing X. Parallel results were obtained in the B5-CREG, where the effector cells lysed target cells bearing B5, B15, B18, or Bw35, all of which bear Y. No lysis was seen with cells not bearing Y. That these public antigens were the determinants actually recognized by the cytotoxic effector cells was demonstrated by the ability of appropriate antibody to inhibit cytolysis. These results suggest possible immunopathogenic mechanisms that may explain the apparent association of X with spondyloarthropathy and of Y with Behçet's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340s-350s
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
HLA public determinants are target antigens of cell-mediated cytotoxicity.
pubmed:publicationType
Journal Article