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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020792,
umls-concept:C0039194,
umls-concept:C0086418,
umls-concept:C0205191,
umls-concept:C0237876,
umls-concept:C0439855,
umls-concept:C1171362,
umls-concept:C1417913,
umls-concept:C1515670,
umls-concept:C1517806,
umls-concept:C1521761,
umls-concept:C1522604
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pubmed:issue |
6
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pubmed:dateCreated |
1980-8-15
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pubmed:abstractText |
In the course of generating monoclonal antibodies to human thymus-dependent differentiation antigens, we were able to define specificities shared by T cells and by cells from patients with chronic lymphatic leukemia that were not detectable on normal B cells. In particular, one of these antibodies was reactive by indirect immunofluorescence with greater than 95% of the thymocytes and 80--95% of nonadherent sheep erythrocyte-rosetting peripheral blood lymphocytes (PBL), but was unreactive with normal B cells or cell lines derived from PBL by Epstein-Barr virus transformation. However, the leukemic cells from 11 of 14 patients with B-type chronic lymphatic leukemia were found to express detectable concentrations of this surface determinant. The target antigen recognized by this monoclonal antibody was shown by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis to be a p69,71 complex. Our findings suggest a possible relationship between this antigen and the previously described GIX system in the mouse.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-1086751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-146728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-147908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-167098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-232686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-302287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-312899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-4351100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-46909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-46910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-5131013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-5576334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-567551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6155425-83236
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1539-44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6155425-Animals,
pubmed-meshheading:6155425-Antigens, Neoplasm,
pubmed-meshheading:6155425-Antigens, Surface,
pubmed-meshheading:6155425-B-Lymphocytes,
pubmed-meshheading:6155425-Cross Reactions,
pubmed-meshheading:6155425-Epitopes,
pubmed-meshheading:6155425-Humans,
pubmed-meshheading:6155425-Leukemia, Lymphoid,
pubmed-meshheading:6155425-Membrane Proteins,
pubmed-meshheading:6155425-Mice,
pubmed-meshheading:6155425-Mice, Nude,
pubmed-meshheading:6155425-Molecular Weight,
pubmed-meshheading:6155425-T-Lymphocytes
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pubmed:year |
1980
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pubmed:articleTitle |
Identification of a p69,71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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