Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1980-6-25
|
| pubmed:abstractText |
The kinetics of CFUc studied by hydroxyurea and endotoxin treatments indicate that this cell population is proliferating actively (some 50% in S-phase). This fact implies a peculiar response to (BLM) treatment with Bleomycin, a drug which appears to be proliferation-dependent. The dose-response has a steep initial slope resulting in a low extrapolation number (n = 0.66; D37 = 960 +/- 70 mg BLM/kg body weight). The steep initial slope is confirmed by split-dose experiments resulting in a potentiation effect by fractionation. Further evidence for the dependence of the action of this drug upon the proliferative state of the cell population is derived from time-response studies after single doses of BLM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0008-8730
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-51
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6153927-Animals,
pubmed-meshheading:6153927-Bleomycin,
pubmed-meshheading:6153927-Cell Division,
pubmed-meshheading:6153927-Dose-Response Relationship, Drug,
pubmed-meshheading:6153927-Endotoxins,
pubmed-meshheading:6153927-Female,
pubmed-meshheading:6153927-Hematopoietic Stem Cells,
pubmed-meshheading:6153927-Hydroxyurea,
pubmed-meshheading:6153927-Kinetics,
pubmed-meshheading:6153927-Mice
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Effect of bleomycin on mouse haemopoietic colony forming cells in culture (CFUc).
|
| pubmed:publicationType |
Journal Article
|