Linked Life Data

6144375

Source:http://linkedlifedata.com/resource/pubmed/id/6144375

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-7-19
pubmed:abstractText
Electrical stimulation of the lateral septum results in a transient cardiodeceleration which may represent parasympathetic rebound to a brief sympathetic activation. Kainic acid (KA) is a potent neuronal excitant. Stimulation of the lateral septum by KA produced a short-latency tachycardia. Vehicle injections, as well as KA administration to adjacent structures, did not effect significant changes in heart rate. Intraventricular KA, however, did result in a significant tachycardia. Knife cuts of the fornix, interrupting the glutamatergic innervation of the septum, completely blocked the cardiovascular response to KA. Pharmacological treatments reducing sympathetic activity prevented or reversed KA-elicited tachycardia. Thus, it appears that septal administration of KA produces sympathetic activation. KA may serve as a useful tool in studies assessing central regulation of the autonomic nervous system, and the interrelationship between autonomic activity and seizure-induced neuronal loss.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-14
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Kainic acid stimulation of the lateral septum elicits tachycardia.
pubmed:publicationType
Journal Article