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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
1 Histamine H2-receptor antagonism by burimamide, metiamide and cimetidine was analysed under apparent equilibrium conditions in the lumen-perfused isolated stomach preparation of the mouse. 2 The behaviour of these compounds was not incompatible with simple competitive antagonism but the estimated pKB values (-log KB) were all significantly lower, by about 1 log unit, than reference values reported for guinea-pig atrium or rat uterus. 3 There seems no need to propose that the parietal cell receptors are somehow different from the others; metiamide continually appears in the gastric juice so that a steady-state but not equilibrium can presumably be reached with respect to the bath concentration and this could keep the antagonist concentration artificially low in the region of the receptors.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-1188
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6132635-Animals,
pubmed-meshheading:6132635-Dose-Response Relationship, Drug,
pubmed-meshheading:6132635-Female,
pubmed-meshheading:6132635-Gastric Acid,
pubmed-meshheading:6132635-Histamine H2 Antagonists,
pubmed-meshheading:6132635-Hydrogen-Ion Concentration,
pubmed-meshheading:6132635-Male,
pubmed-meshheading:6132635-Metiamide,
pubmed-meshheading:6132635-Mice,
pubmed-meshheading:6132635-Receptors, Histamine H2
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pubmed:year |
1980
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pubmed:articleTitle |
Estimation of pKB values for histamine H2-receptor antagonists using an in vitro acid secretion assay.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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