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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20-21
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pubmed:dateCreated |
1983-4-21
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pubmed:abstractText |
Male F344 rats were trained to discriminate between saline and d,l-ethylketazocine (EKC) in a two-choice discrete-trial avoidance task and tested with the l- and d-isomers of EKC, cyclazocine, and SKF-10,047. The effectiveness of naloxone in antagonizing the discriminative effects of d,l-EKC was also determined. Each of the l-isomers tested produced dose-related stimulus control of behavior similar to that produced by d,l-EKC. l-EKC was the most potent isomer tested, being approximately twice as potent as d,l-EKC. In contrast, d-EKC was completely devoid of activity at 300-fold higher doses. l-Cyclazocine and l-SKF-10,047 were approximately 4- and 30-fold less potent, respectively, than d,l-EKC. Although both d-cyclazocine and d-SKF-10,047 produced some drug-appropriate responding, both compounds were less potent and less efficacious than their respective l-isomers and both were significantly less efficacious than d,l-EKC. Increasing doses of naloxone (0.1 - 1.0 mg/kg) produced parallel shifts to the right in the d,l-EKC dose-effect curve. These results suggest that the discriminative effects of EKC are mediated by a stereospecific naloxone-sensitive receptor.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclazocine,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylketocyclazocine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Phenazocine,
http://linkedlifedata.com/resource/pubmed/chemical/SK&F 10047
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2371-4
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6131363-Analgesics, Opioid,
pubmed-meshheading:6131363-Animals,
pubmed-meshheading:6131363-Avoidance Learning,
pubmed-meshheading:6131363-Cyclazocine,
pubmed-meshheading:6131363-Discrimination (Psychology),
pubmed-meshheading:6131363-Drug Antagonism,
pubmed-meshheading:6131363-Ethylketocyclazocine,
pubmed-meshheading:6131363-Male,
pubmed-meshheading:6131363-Naloxone,
pubmed-meshheading:6131363-Phenazocine,
pubmed-meshheading:6131363-Rats,
pubmed-meshheading:6131363-Rats, Inbred F344,
pubmed-meshheading:6131363-Stereoisomerism,
pubmed-meshheading:6131363-Structure-Activity Relationship
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pubmed:articleTitle |
Discriminative effects of ethylketazocine in the rat: stereospecificity and antagonism by naloxone.
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pubmed:publicationType |
Journal Article
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