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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8320
|
pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Two groups of outpatients (7 in each group) with Raynaud's syndrome, matched for severity of illness, were randomly allocated to receive at weekly intervals for three weeks either a 5 h intravenous infusion of buffer or epoprostenol (prostacyclin, PGI2) in buffer (7.5 ng/kg/min after the first hour). PGI2 reduced the frequency and duration of ischaemic attacks (both p less than 0.01). Hand temperature measurements with a thermocouple were significantly improved at 1 week; 6 weeks after the last infusion hand temperatures had returned to baseline. There was a corresponding loss of clinical response 8-10 weeks after the last infusion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0140-6736
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
12
|
pubmed:volume |
1
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6130329-Clinical Trials as Topic,
pubmed-meshheading:6130329-Double-Blind Method,
pubmed-meshheading:6130329-Epoprostenol,
pubmed-meshheading:6130329-Female,
pubmed-meshheading:6130329-Humans,
pubmed-meshheading:6130329-Infusions, Parenteral,
pubmed-meshheading:6130329-Ischemia,
pubmed-meshheading:6130329-Male,
pubmed-meshheading:6130329-Microcirculation,
pubmed-meshheading:6130329-Platelet Aggregation,
pubmed-meshheading:6130329-Prostaglandins,
pubmed-meshheading:6130329-Random Allocation,
pubmed-meshheading:6130329-Raynaud Disease,
pubmed-meshheading:6130329-Skin,
pubmed-meshheading:6130329-Skin Temperature
|
pubmed:year |
1983
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pubmed:articleTitle |
Intermittent epoprostenol (prostacyclin) infusion in patients with Raynaud's syndrome. A double-blind controlled trial.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Controlled Clinical Trial
|