Linked Life Data

6129738

Source:http://linkedlifedata.com/resource/pubmed/id/6129738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-2-14
pubmed:abstractText
We have previously shown that the growth response of the rat thyroid to a sustained elevation of the serum level of TSH, induced by goitrogen administration, is self-limiting. This study investigated the possibility that this limitation of growth is due to the inhibitory action of a chalone secreted by the thyroid follicular cells, the serum concentration of which increases as the gland grows. Twenty-seven adult rats were treated with the goitrogen aminotriazole for 5 months to reach a 'plateau of growth'. One group of 9 rats was then subjected to hemithyroidectomy, another to a sham operation, while a third acted as unoperated controls. Four weeks later there was no significant difference between the groups in thyroid weight, follicular cell number or serum TSH. The absence of regeneration following hemithyroidectomy indicates that a systemically-circulating chalone does not play a role in the regulation of growth in the goitrous thyroid. Other mechanisms including the possible role of a 'local' chalone are briefly discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-6075
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Investigation of putative control mechanisms for thyroid growth.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't