Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1982-10-12
|
| pubmed:abstractText |
Nifedipine, a calcium-channel blocker, differs in structure and mode of action not only from the nitrates and beta blockers but also from the other well-known calcium-channel blockers. These differences have important implications for the treatment of angina pectoris. Our clinical experience over a period of 6 years with all types of angina patients--mostly those with chronic stable angina but also those with Prinzmetal's and unstable angina-corroborates the efficacy reports published in the world literature. Although the safety profile of nifedipine has been generally regarded as favorable, a few reports of clinically significant adverse effects in specific patient groups have appeared in the literature. In order to provide a more comprehensive assessment of safety, the records of over 3000 patients treated with nifedipine in open and controlled multiple-dose studies were tabulated and analyzed. Of special concern were patients with clinically significant adverse experiences, patients with a concomitant diagnosis of congestive heart failure (CHF), patients who were being treated concurrently with beta blockers, and patients who had been taking nifedipine for more than 6 months. Results of this analysis confirm that nifedipine can be safely administered to a broad spectrum of angina patients, including those with a concomitant diagnosis of CHF and those receiving concurrent therapy with beta-blocking agents.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Nifedipine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
681-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6126114-Adrenergic beta-Antagonists,
pubmed-meshheading:6126114-Adult,
pubmed-meshheading:6126114-Aged,
pubmed-meshheading:6126114-Angina Pectoris,
pubmed-meshheading:6126114-Angina Pectoris, Variant,
pubmed-meshheading:6126114-Calcium Channel Blockers,
pubmed-meshheading:6126114-Dizziness,
pubmed-meshheading:6126114-Drug Therapy, Combination,
pubmed-meshheading:6126114-Edema,
pubmed-meshheading:6126114-Female,
pubmed-meshheading:6126114-Heart Failure,
pubmed-meshheading:6126114-Humans,
pubmed-meshheading:6126114-Male,
pubmed-meshheading:6126114-Middle Aged,
pubmed-meshheading:6126114-Nausea,
pubmed-meshheading:6126114-Nifedipine,
pubmed-meshheading:6126114-Nitrates,
pubmed-meshheading:6126114-Pyridines,
pubmed-meshheading:6126114-Water-Electrolyte Balance
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Nifedipine therapy in angina pectoris: evaluation of safety and side effects.
|
| pubmed:publicationType |
Journal Article
|