Linked Life Data

6125257

Source:http://linkedlifedata.com/resource/pubmed/id/6125257

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1982-10-29
pubmed:abstractText
Expression of gamma-glutamyl transpeptidase (GGT) in the developing mouse tooth, intervertebral disc, and hair follicle was investigated in terms of its localization during ontogenic stages and its association or lack of association with cell proliferation (labeled nuclei after [3H]thymidine injection or metaphase-arrested cells after colchicine injection). The data demonstrate that (a) GGT expression followed a program of activity and localization changes that correlated with the progressive emergence of developmental stages and (b) GGT activity in developing tissues derived either from epithelium (enamel-producing cells and hair follicle cells) or from mesenchyme (intervertebral disc cells) was localized only in mitotically quiescent cellular layers or regions associated with the production of specialized tissue products; however, not all postmitotic regions expressed GGT activity. Although further research is needed to clarify the role of GGT in normal and neoplastic tissues, we conclude that increasing evidence from this and other laboratories implicates GGT as a marker of cell differentiation, cell aging, and/or reduced cell proliferation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4143-52
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Expression of gamma-glutamyl transpeptidase activity in the developing mouse tooth, intervertebral disc, and hair follicle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't