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pubmed:abstractText |
Clinical studies were performed with groups of patients with ischaemic heart disease, patients with hyperthyroidism, and normal subjects, to investigate the possibility of a beta blocker withdrawal syndrome, by measurments of heart rate under conditions of increased sympathetic drive provided by standing with vasodilatation or by Valsalva's manoeuvre. A rebound increase in heart rate to levels significantly higher than the control heart rate off treatment was observed 2-5 days after stopping one or more weeks' treatment with dl-propranolol (160 mg/day), atenolol (200 mg/day), acebutolol (400 mg/day) or oxprenolol (160 mg/day).
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