|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009324,
umls-concept:C0021246,
umls-concept:C0033554,
umls-concept:C0036078,
umls-concept:C0085732,
umls-concept:C0086418,
umls-concept:C0227349,
umls-concept:C0870883,
umls-concept:C1280500,
umls-concept:C1524026,
umls-concept:C1533691
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1982-8-7
|
|
pubmed:abstractText |
1 Homogenates of mucosa from human colon metabolize [3H]-prostaglandin E1 in the presence of nicotinamide adenine dinucleotide to 15-oxo prostaglandin E1 or 15-oxo, 13,14 dihydro prostaglandin E1. 2 Metabolic capacity of tissue from patients with active ulcerative colitis under treatment with sulphasalazine (0.021 +/- 0.004 nmol/Mg protein +/- s.e. mean) did not differ from mucosa of normal patients (0.02 +/- 0.004 nmol/mg protein) during 1 h incubation. 3 Sulphasalazine inhibits prostaglandin E1 metabolism by mucosal homogenates in a dose-dependent manner with an ID50 of 125 microM. Its therapeutically active metabolite, 5-aminosalicylic acid (2.6 mM) was without significant inhibitory activity. 4 Indomethacin inhibits prostaglandin E1 metabolism by colonic mucosa with an ID50 of 388 microM. 5 At present we cannot clearly relate the therapeutic benefit of sulphasalazine and its therapeutically active metabolite, 5-aminosalicylic acid, in ulcerative colitis to their effects on prostaglandin E synthesis or metabolism in vitro.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-101423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-13994348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-14238045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-30669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-358989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-367886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-40848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-4854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6103724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6113614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6114012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6114307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6116944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6965522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-6990725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-72239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-7384557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-7429111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-7429322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6123357-983858
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
157-61
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6123357-Alprostadil,
pubmed-meshheading:6123357-Aminosalicylic Acids,
pubmed-meshheading:6123357-Colitis, Ulcerative,
pubmed-meshheading:6123357-Colon,
pubmed-meshheading:6123357-Humans,
pubmed-meshheading:6123357-Indomethacin,
pubmed-meshheading:6123357-Intestinal Mucosa,
pubmed-meshheading:6123357-Prostaglandins,
pubmed-meshheading:6123357-Prostaglandins E,
pubmed-meshheading:6123357-Sulfasalazine
|
|
pubmed:year |
1982
|
|
pubmed:articleTitle |
Ulcerative colitis: effect of sulphasalazine, its metabolites and indomethacin on the ability of human colonic mucosa to metabolize prostaglandins in vitro.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
