| pubmed-article:6117393 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6117393 | lifeskim:mentions | umls-concept:C0026056 | lld:lifeskim |
| pubmed-article:6117393 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:6117393 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6117393 | pubmed:dateCreated | 1982-1-28 | lld:pubmed |
| pubmed-article:6117393 | pubmed:abstractText | The effect-kinetics of the new benzodiazepine midazolam was evaluated in six subjects after single oral (7.5 and 15 mg) and intravenous (0.075 mg/kg) doses and infusion programs. The drug is bound to plasma proteins by 94%, and less than 0.5% is excreted unchanged in urine. Hepatic elimination is rapid: t1/2 beta is 2.4 +/- 0.8 hr (mean +/- S.D) and total body clearance is 283 +/- 43 ml/min (plasma) or 502 +/- 105 ml/min (blood). This substantial first-pass effect leads to bioavailability of only 44%, despite very rapid absorption (t1/2abs = 0.23 +/- 0.37 hr) after oral dosing. There is good intraindividual linear correlations (r between 0.68 and 0.97) between plasma levels and dynamic effects, as assessed by the d2 letter cancellation test and a sedation index formed from visual analogue scales. | lld:pubmed |
| pubmed-article:6117393 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6117393 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6117393 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6117393 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6117393 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6117393 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:6117393 | pubmed:author | pubmed-author:KlotzUU | lld:pubmed |
| pubmed-article:6117393 | pubmed:author | pubmed-author:AllonenHH | lld:pubmed |
| pubmed-article:6117393 | pubmed:author | pubmed-author:ZieglerGG | lld:pubmed |
| pubmed-article:6117393 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6117393 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:6117393 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6117393 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6117393 | pubmed:pagination | 653-61 | lld:pubmed |
| pubmed-article:6117393 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:6117393 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6117393 | pubmed:articleTitle | Midazolam kinetics. | lld:pubmed |
| pubmed-article:6117393 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6117393 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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