Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-5-13
pubmed:abstractText
1. The cardiovascular effects of morphine, fentanyl, [D-Ala2]-met-enkephalinamide were analyzed after intracisternal injection in anaesthetized rats. PaO2 was measured as an index of respiratory function. 2. At low doses in spontaneously breathing rats, morphine, fentanyl and [D-Ala2]-met-enkephalinamide induced a pressor response with slight tachycardia and no significant change in PaO2. 3. The pressor response appeared to be due to activation of opiate receptors and mediated through the sympathetic nervous system. 4. High doses of morphine and [D-Ala2]-met-enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats. A marked reduction in PaO2 was found during the depressor phase. 5. High doses of [D-Ala2]-met-enkephalinamide produced only a pressor response in artificially-ventilated rats with no signs of secondary hypotension. 6. Our data support the idea that morphinomimetic agents are centrally pressor at low doses in the rat. The respiratory depression observed with high doses may be the cause of hypotension.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-1034219, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-190683, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-191149, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-220062, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-282060, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-4154206, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-4611773, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-597727, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-622192, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-639859, http://linkedlifedata.com/resource/pubmed/commentcorrection/6110456-923652
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Central cardiovascular effects of narcotic analgesics and enkephalins in rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't