Linked Life Data

6108077

Source:http://linkedlifedata.com/resource/pubmed/id/6108077

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Bypass of large segments of the small intestine to produce weight loss in morbidly obese human subjects has been associated with increased lipid accumulation in the liver. Congenital and nutritional obese rat models were employed to evaluate hepatic lipid accumulation following bypass of 90% of the small intestine. When small intestinal bypass was performed on nutritionally obese rats ingesting a high-fat diet (17%) supplemented with choline dihydrogen citrate (3,4 g/kg diet), a 59% loss of weight at 1 mo was unassociated with increased hepatic lipid accumulation when compared to sham-operated controls. When small intestinal bypass was performed on a nutritionally obese rat fed a relative choline-methionine-deficient diet following intestinal bypass, marked increases in total hepatic lipid and hepatic triglyceride content were evident when compared to the lipid content in sham-operated controls ingesting a similar choline-deficient diet. Hepatic steatosis following small intestinal bypass could be produced in a rat model only by a deficiency in a required substrate for triglyceride conversion to phospholipid and suggests that similar deficiencies may contribute to the increased hepatic lipid accumulation occurring in human subjects following intestinal bypass.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
239
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G358-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of small intestinal bypass on hepatic lipid accumulation in rats.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.