Linked Life Data

6107858

Source:http://linkedlifedata.com/resource/pubmed/id/6107858

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5785
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Earlier work has suggested that aspartate, glutamate and gamma-aminobutyric acid (GABA) act as transmitters in the cerebral cortex. There is reasonable evidence for the identity of the cell population responsible for GABA release but until now there has been little evidence concerning the sources for release of aspartate and glutamate. Here we have used two approaches to identify possible neurotransmitters used by cells in the visual cortex: measurement of the efflux of endogenous compounds in conditions of synaptic release and localization of these compounds to particular cell classes using neurotransmitter-specific histochemical techniques. Our results suggest that the acidic amino acids aspartate and glutamate may be cortical neurotransmitters, as shown by calcium-dependent release from endogenous stores and by uptake specific to pyramidal cells in layer 6 of the cortex. These substances may therefore have a role in the function of layer 6 cells, which are responsible for the recurrent projection from the cortex to the lateral geniculate nucleus and for the projection within the cortex from layer 6 to layer 4.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
287
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
848-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Aspartate and glutamate as possible neurotransmitters of cells in layer 6 of the visual cortex.
pubmed:publicationType
Journal Article, In Vitro