Linked Life Data

6105927

Source:http://linkedlifedata.com/resource/pubmed/id/6105927

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1980-11-20
pubmed:abstractText
We have isolated from extracts of ovine hypothalamus two molecules characterized as somatostatin-28 and somatostatin-4-28 (referred to as somatostatin-25). They were reproduced by synthesis. In equimolar ratios and depending upon the experimental conditions, synthetic somatostatin-28 and somatostatin-25 are 3 to 14 times more potent than somatostatin-14 to inhibit the basal in vitro secretion of growth hormone. These results suggest that somatostatin-14 as originally isolated, is a biologically active fragment of a larger molecule of greater specific activity, rather than somatostatin-28 being a precursor of the tetradecapeptide.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0567-655X
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1369-71
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
[High biological activity of the synthetic counterparts of hypothalamic somatostatin-28 and somatostatin-25].
pubmed:publicationType
Journal Article, English Abstract