Linked Life Data

6103647

Source:http://linkedlifedata.com/resource/pubmed/id/6103647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-7-26
pubmed:abstractText
The three-ion test still appears to be the best electrophysiological tool available to define the molecular mechanisms involved in activation of a given ionophore. New insights into synaptic mechanisms require the investigator to be alert to possible exceptional cases. In general, the treatment of the exceptional case is validly accomplished once the diagnosis is made. It is important to determine the Nernstian behavior of the reversal potential and to identify the ions that participate in the synaptic process, as well as to determine whether the conductances for these ions increase or decrease. Noise analysis, although measuring properties of the synaptic ionophore, seems the most promising physiological tool for identification of the transmitter recognition moiety of the receptor, since the open time appears to be a function of binding. It remains to develop stringent methodology for analyzing channel open time during the physiological event.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The reversal potential as a diagnostic tool in transmitter identification.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.