rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-4-26
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pubmed:abstractText |
Rat isolated intestine incubated in Krebs solution converted exogenous [14C]arachidonic acid into products that chromatographed with prostaglandins, leukotriene B4 and 5-hydroxy-eicosatetraenoic acid. The accumulation of these products was increased by phenolphthalein 3.14-1570 microM and reduced by indomethacin 2.8 microM. This raises the possibility that laxation by phenolphthalein involves the formation of arachidonate lipoxygenase and cyclo-oxygenase products.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5-hydroxy-6,8,11,14-eicosatetraenoic...,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate Lipoxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Cathartics,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyeicosatetraenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene B4,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Phenolphthalein,
http://linkedlifedata.com/resource/pubmed/chemical/Phenolphthaleins,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6099279-Animals,
pubmed-meshheading:6099279-Arachidonate Lipoxygenases,
pubmed-meshheading:6099279-Cathartics,
pubmed-meshheading:6099279-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:6099279-Intestines,
pubmed-meshheading:6099279-Leukotriene B4,
pubmed-meshheading:6099279-Lipoxygenase,
pubmed-meshheading:6099279-Male,
pubmed-meshheading:6099279-Phenolphthalein,
pubmed-meshheading:6099279-Phenolphthaleins,
pubmed-meshheading:6099279-Prostaglandins,
pubmed-meshheading:6099279-Rats,
pubmed-meshheading:6099279-Rats, Inbred Strains,
pubmed-meshheading:6099279-Stimulation, Chemical
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pubmed:year |
1984
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pubmed:articleTitle |
The production of arachidonate lipoxygenase products by rat intestine is increased by phenolphthalein.
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pubmed:publicationType |
Journal Article,
In Vitro
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