Linked Life Data

6097776

Source:http://linkedlifedata.com/resource/pubmed/id/6097776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-3-14
pubmed:abstractText
The mechanism by which interferon (IFN) and interleukin 2 (IL-2) activate NK cells has been examined. Added alone, either lymphokine activates NK cells; together they synergize. NK cells generated by IFN, IL-2 or IFN plus IL-2 are indistinguishable on the basis of their cell surface phenotype. Precursor NK cells are Qa5+, MK 2.2-, Ly-6- and effector NK cells are Qa5+, MK 2.2+, Ly-6+. Sequential factor addition showed that IFN must be present at the start of culture, whereas IL-2 could be added later with no loss of effect. Antibody to IFN was shown to block not only the action of IFN but also to prevent NK cell activation by IL-2. These results are taken to suggest that IFN initiates NK cell activation and IL-2 controls later stages. The synergistic effect of IL-2 is counteracted by cAMP. Considering the variety of systems in which IL-2 is active and the diversity of its effects, it is proposed that its antagonism with cAMP may be a basis for the biologic activity of IL-2.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-6766
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Modulation of interferon-induced NK cells by interleukin 2 and cAMP.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S.