Linked Life Data

6096728

Source:http://linkedlifedata.com/resource/pubmed/id/6096728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-2-21
pubmed:abstractText
The postsynaptic alpha-adrenoceptors of rabbit ear artery, dog splenic artery and dog splenic vein were characterized in vitro by the use of the selective antagonists prazosin (alpha 1) and rauwolscine (alpha 2). In isolated segments of rabbit ear artery, prazosin was a potent antagonist of norepinephrine-induced contraction, with a receptor dissociation constant (KB) of 6.4 nM. In contrast, rauwolscine was effective only at very high concentrations (KB = 4,000 nM), suggesting that the alpha-receptor of the ear artery has conventional alpha 1-characteristics. The opposite order of potency was observed in a presynaptic alpha-receptor model, the isolated guinea pig atrium, where rauwolscine was potent (KB = 4.5 nM) and prazosin essentially inactive. Rauwolscine had an intermediate potency in the dog splenic vasculature, with a KB of 125 nM in splenic arterial segments and 5-15 nM in segments or helical strips of splenic vein. In contrast to the results with rauwolscine, prazosin was essentially equipotent in dog and rabbit tissues as an antagonist of norepinephrine-induced contraction (KB = 3-9 nM). Schild analysis showed competitive antagonism for both rauwolscine and prazosin in all tissues. These results are consistent with the presence of a homogeneous population of alpha-receptors in dog vasculature having characteristics of both the alpha 1 and alpha 2 receptor subtypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-1298
pubmed:author
pubmed:issnType
Print
pubmed:volume
328
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
44-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Different characteristics of postjunctional alpha-adrenoceptors on arterial and venous smooth muscle.
pubmed:publicationType
Journal Article, In Vitro