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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1984-12-13
|
| pubmed:abstractText |
Various studies were conducted to evaluate the effects of timolol, an S-enantiomer, relative to its R-enantiomer upon intraocular pressure and related ocular systems in the rabbit. The R-enantiomer was about one-third as potent as timolol in displacing 3H-dihydroalprenolol binding to iris-ciliary body tissue, reducing aqueous humor formation, and lowering intraocular pressure of alpha-chymotrypsin hypertensive eyes. In contrast, the R-enantiomer was 50 to 90 times less potent than timolol in antagonizing the effects of isoproterenol on pulmonary and atrial beta-adrenergic receptors. The data indicate that the R-enantiomer may lower intraocular pressure in man at concentrations less likely than timolol to block extraocular beta-adrenergic receptors. Finally, to account for the differential effect of the R-enantiomer upon ocular as opposed to extraocular beta-adrenergic receptors, it is tentatively suggested that this agent may also act upon a population of ocular beta-adrenergic receptors showing relatively poor stereoselectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0721-832X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
221
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
234-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6092239-Animals,
pubmed-meshheading:6092239-Aqueous Humor,
pubmed-meshheading:6092239-Binding Sites,
pubmed-meshheading:6092239-Bronchi,
pubmed-meshheading:6092239-Chymotrypsin,
pubmed-meshheading:6092239-Ciliary Body,
pubmed-meshheading:6092239-Dihydroalprenolol,
pubmed-meshheading:6092239-Dose-Response Relationship, Drug,
pubmed-meshheading:6092239-Female,
pubmed-meshheading:6092239-Glaucoma,
pubmed-meshheading:6092239-Guinea Pigs,
pubmed-meshheading:6092239-Humans,
pubmed-meshheading:6092239-Intraocular Pressure,
pubmed-meshheading:6092239-Iris,
pubmed-meshheading:6092239-Male,
pubmed-meshheading:6092239-Ocular Hypertension,
pubmed-meshheading:6092239-Rabbits,
pubmed-meshheading:6092239-Receptors, Adrenergic, beta,
pubmed-meshheading:6092239-Time Factors,
pubmed-meshheading:6092239-Timolol,
pubmed-meshheading:6092239-Trachea
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
R-enantiomer of timolol: a potential selective ocular antihypertensive agent.
|
| pubmed:publicationType |
Journal Article
|