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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5979
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pubmed:dateCreated |
1984-9-26
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pubmed:abstractText |
In BALB/c-3T3 cells, expression of the c-myc gene is stimulated by platelet-derived growth factor (PDGF). Using mouse mammary tumour virus promoter: c-myc recombinant plasmids, 3T3 sublines were constructed in which hydrocortisone was the primary determinant of myc mRNA content. The c-myc gene product is an intracellular mediator of the growth response to PDGF though probably not the only one. Both the human and the mouse c-myc genes stimulate clonal growth of 3T3 cells in PDGF-free medium suggesting new strategies for analysis of oncogenes which do not function in focus formation assays.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
310
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
655-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6088986-Animals,
pubmed-meshheading:6088986-Cell Transformation, Neoplastic,
pubmed-meshheading:6088986-Cells, Cultured,
pubmed-meshheading:6088986-DNA, Recombinant,
pubmed-meshheading:6088986-DNA Replication,
pubmed-meshheading:6088986-Epidermal Growth Factor,
pubmed-meshheading:6088986-Hydrocortisone,
pubmed-meshheading:6088986-Mammary Tumor Virus, Mouse,
pubmed-meshheading:6088986-Mice,
pubmed-meshheading:6088986-Mice, Inbred BALB C,
pubmed-meshheading:6088986-Oncogenes,
pubmed-meshheading:6088986-Plasmids,
pubmed-meshheading:6088986-Platelet-Derived Growth Factor,
pubmed-meshheading:6088986-Simplexvirus,
pubmed-meshheading:6088986-Transfection
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pubmed:articleTitle |
Functional role for c-myc in mitogenic response to platelet-derived growth factor.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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