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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1967-12-16
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pubmed:abstractText |
1. The membrane conductance of the crayfish muscle fibre was calculated and the increase in the membrane conductance brought about by the application of gamma-aminobutyric acid (GABA) was investigated under various conditions. The permeability of the activated inhibitory post-synaptic membrane was estimated from the conductance change.2. When the concentration of Cl(-) was changed by substituting Cl(-) with methylsulphate, a linear relation was obtained between the membrane conductance change produced by GABA and the concentration of Cl(-). Cations have no appreciable effect on the GABA induced conductance change (less than 0.4%).3. The conductance change produced by GABA on the inhibitory post-synaptic membrane was measured in various solutions in which the Cl(-) was replaced by various anions. The degree of permeability depended on the anion species in the following order:Br(-) > Cl(-) > SCN(-) > I(-) > NO(3) (-) > HCOO(-) > ClO(3) (-) > ClO(4) (-) > BrO(3) (-)4. At high pH the conductance change produced by GABA was decreased, while at low pH it increased.5. These results show that the activated inhibitory post-synaptic membrane of crayfish muscle fibres has the characteristics of an anion selective membrane, suggesting the fixed positive charges in the inhibitory membrane.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13000763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13278905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13542169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13599117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13631206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13642302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13724752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13861983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13889686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-13956993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14089023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14104936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14158590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14165167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14301023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14425197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-14482238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-16992221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-18128147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6051794-5230136
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
191
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
575-90
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
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pubmed:year |
1967
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pubmed:articleTitle |
Anion permeability of the inhibitory post-synaptic membrane of the crayfish neuromuscular junction.
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pubmed:publicationType |
Journal Article
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