Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1978-3-10
|
pubmed:abstractText |
To evaluate the role of reduced erythropoietin (Ep) production in the pathogenesis of dialysis anaemia, measurements of serum erythropoietin (SEp) concentration by means of a highly sensitive in vitro bioassay were performed in 88 non-nephrectomised non-transfused regular haemodialysis patients. In 50 patients (group 1) SEp levels were lower than 120 mU/ml. In the remaining 38 patients (group 2) SEp concentrations ranged from 120-369 mU/ml. Group 1 showed a highly significant positive correlation between SEp concentration and haematocrit as did 13 anephric patients investigated for comparison. In contrast, group 2 displayed a highly significant negative correlation between SEp concentration and haematocrit. The results demonstrate the existence of two distinctive groups of similar size in regular haemodialysis patients: those with an absolute (group 1) and those with a relative deficiency of Ep (group 2). In the case of the latter, lack of Ep is probably a secondary factor in the pathogenesis of anaemia, whereas uraemic toxicity and blood loss may play a primary role.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0071-2736
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
177-83
|
pubmed:dateRevised |
2008-2-21
|
pubmed:meshHeading | |
pubmed:year |
1977
|
pubmed:articleTitle |
The variable role of erythropoietin deficiency in the pathogenesis of dialysis anaemia.
|
pubmed:publicationType |
Journal Article
|