Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1978-2-18
|
| pubmed:abstractText |
Plasma renin activity (PRA) was stimulated by oral frusemide (60 mg) in 4 normal male subjects. Cyproheptadine (Periactin), a serotonin antagonist, was then administered (2 mg orally four times daily) for 7 days and the PRA response to frusemide re-evaluated in the 4 subjects. A highly significant mean inhibition (P less than 0.01) of frusemide stimulated PRA was demonstrated after cyproheptadine administration. Our results show that serotonin, presumably acting via central pathways, may play a role in renin regulation and that this pathway can be inhibited by cyproheptadine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1235-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1977
|
| pubmed:articleTitle |
Cyproheptadine inhibition of stimulated plasma renin activity.
|
| pubmed:publicationType |
Journal Article
|