Linked Life Data

589469

Source:http://linkedlifedata.com/resource/pubmed/id/589469

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-2-18
pubmed:abstractText
Pigeon retinae were analyzed for binding [125I]alpha-bungarotoxin (alphaBgt) by radioautographic and biochemical methods. Toxin binding, localized to the outer and inner plexiform layers (OPL and IPL), was inhibited by micromolar concentrations of native alphaBgt and D-tubocurarine and by 1 mM acetyl- and butyrylcholine in both synaptic layers. Nicotine, at comparable concentrations affected only the IPL. In vitro drug competition experiments showed that the pigeon retina contains two types of receptors for alphaBgt which differ in sensitivity to inhibition by nicotine by 4 orders of magnitued. The results suggest that: (1) the receptor for alphaBgt in the IPL is a nicotinic receptor, (2) the receptor for alphaBgt in the OPL may be involved in an unusual cholinergic system, and (3) ability to bind alphaBgt is not a sufficient criterion for identifying nicotinic-cholinergic receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-57
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Two types of receptors for alpha-bungarotoxin in the synaptic layers of the pigeon retina.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.